SAHA increases chaperone expression and reduces Z-alpha-1-antitrypsin polymers in a patient specific iPSC-based liver model for alpha-1-antitrypsin deficiency
Nina Graffmann, Rabea Hokamp, Christiane Loerch, Malin Fromme, Wasco Wruck, Pavel Strnad, James Adjaye
The paper uses iPSC-derived liver cells to show SAHA reduces Z-alpha-1-antitrypsin polymers by increasing chaperone expression in AATD models.
Stem Cell Research & Therapy · Oct 27, 2026Peer-reviewedCell Biology