GEM-GPT Enables Personalized Cell Type-Resolved Therapeutic Design for Systems Pharmacology
Shuo Zhang, Rahul Ohlan, Mohammadsadeq Mottaqi, Lei Xie
GEM-GPT generates personalized therapeutic molecules to shift cell-type-specific disease states toward healthy phenotypes, outperforming baselines in chemical perturbation and CRISPR experiments.
bioRxiv · Sep 12, 2026 · PreprintPharmacology & Toxicology