SpaReg: sparsity-based 3D reconstruction of tissue microenvironments at native resolution across morphological and spatial molecular modalities
Rajdeep Pawar, Thomas Jacob, Rebecca Raphael, Elaine Byrnes, Simon C. Watkins, Thing Rinda Soong, Aatur Dilip Singhi, Shikhar Uttam
SpaReg reconstructs 3D tissue microenvironments from histology, spatial proteomics, and spatial transcriptomics data, preserving morphology and enabling accurate classification and disease modeling.
bioRxiv · Sep 29, 2026 · PreprintSystems Biology