DecoderTCR: Compositional Pretraining and Entropy-Guided Decoding for TCR-pMHC Interactions
Ben Lai, Melissa Englund, Ramit Bharanikumar, Isabel Nocedal, Ali Davariashtiyani, Jason F. Perera, Aly Azeem Khan
DecoderTCR improves TCR-pMHC interaction prediction using pretraining and entropy-guided decoding, achieving high AUROC scores without epitope-specific training.
bioRxiv · Feb 6, 2026 · PreprintBioinformatics