KRAS-driven metabolic reprogramming of enhanced MFSD2A-mediated lysophosphatidylcholine scavenging promotes survival and progression of pancreatic ductal adenocarcinoma
Yihui Chen, Cason Haffner, Benson Chellakkan Selvanesan, Ranran Wu, Riccardo Ballarò, Ana Vilchis Celis, Mingxin Zuo, LaNisha L. Patterson, Michael Adofo, Jody Vykoukal, Ricardo A. Léon-Letelier, Rongzhang Dou, Soyoung Park, Yining Cai, Daniela Rodriguez-Perera, , Johannes Francois Fahrmann
This study identifies KRAS-driven metabolic reprogramming through MFSD2A-mediated lysophosphatidylcholine scavenging as a driver of PDAC progression and shows that targeting this pathway with edelfosine has anti-cancer effects.
bioRxiv · Oct 6, 2026 · PreprintCancer Biology