Lysosomal Expansion Compartments Mediate Zinc and Copper Homeostasis in Caenorhabditis elegans
Joy R Armendariz, Sean Teng, Camdyn Rakow, Raquel Herrera, Samuel Herrera, Moshe T. Gordon, Si Chen, Stefan Vogt, Hanwenheng Liu, Makena Jarvis, Katryna Reese, Aidan T. Pezacki, Christopher J. Chang, Byung-Eun Kim, Daniel L. Schneider, , Kerry Kornfeld
The paper shows that lysosomes in C. elegans expand to store zinc, copper, and manganese, with metal transporters localizing to both acidified and expansion compartments.
Metallomics · Jan 1, 2026Peer-reviewedMolecular Biology