N6-methyladenosine promotes temozolomide resistance through non-canonical regulation of mRNA stability in glioblastoma cells
Emily A. Dangelmaier, Dorthy Fang, Isabel Hardy, Kyal Sin Htet, Nicole S. Harry, Renee Pascoe, Je Won Yang, Clara D. Wang, Sigrid Nachtergaele
This study shows that m6A methylation stabilizes genes involved in temozolomide resistance in glioblastoma, and inhibiting METTL3 can restore drug sensitivity.
NAR Cancer · Sep 15, 2026Peer-reviewedMolecular Biology