Tfh dysfunction is associated with poor responses to HBV vaccination
Han M. Chen, Elizabeth Severa, Xiaomin Yao, Tijaana Williams, Riddhimaa Sinha, Clarice Monteiro, Michael Tuen, Thomas Barnett Dubensky, Sergei B. Koralov, Carla R. Nowosad, Derek A. Oldridge, Laura A. Vella, Anoma Nellore, Ramin S. Herati
HBV vaccine-draining lymph node biopsies tie low antibody titers to reduced, interferon-skewed GNG4+ germinal center T follicular helper cells; public B cell clonotypes did not track response.
bioRxiv · Sep 30, 2026 · PreprintImmunology✦ In-depth digest