Polarization of regulatory inputs reveals structural constraints in reconstructed pathway-associated regulatory networks
Anna Procopio, Rita Granata, Paolo Zaffino, Alessio Merola, Francesco Amato, Carlo Cosentino
The paper introduces a framework to analyze regulatory network polarization and finds that mixed-input targets are systematically depleted in pathway-associated networks.
bioRxiv · Oct 16, 2026 · PreprintSystems Biology