Dual inhibition of p38α MAPK and Casein kinase δ/ϵ as a novel treatment strategy for AR-independent and taxane-resistant advanced prostate cancer
Sayak Chakravarti, Suman Mazumder, Farnaz Hemmati, Farshad Amiri, Sarah Batten, Panagiotis Mistriotis, Robert Arnold, Ujjal Kumar Mukherjee, Taraswi Mitra Ghosh, Amit Mitra
This paper demonstrates that TAK-715, a dual inhibitor of p38α MAPK and casein kinase δ/ϵ, effectively treats taxane-resistant and aggressive prostate cancer by targeting cancer stemness and mitochondrial dysfunction.
bioRxiv · Sep 30, 2026 · PreprintCancer Biology