Design of full-length agonist and antagonist antibodies for hard targets
Robin A. Aglietti, Ramin Ansari, Peter M. Bowers, Tim-Henrik Buelles, Hadrien Chauvin, Thibault M. Duplay, Mohamed El Hibouri, Julien Jorda, Joshua Laniado, Matthias M. A. Malago, Kyle Meador, Anya Polovina, Katty Polyak, Justyna Sosna, Robert Tacke, , Lucas Zanini
This paper designs full-length agonist and antagonist antibodies for hard targets using a computational pipeline, achieving nanomolar affinities and functional activity.
bioRxiv · Oct 26, 2026 · PreprintMolecular Biology