An improved CRISPR-LICHT screen of 120 Tdark genes illuminates new biologically relevant SOX2 targets in human brain organoids
Giorgia Pozzolini, Simon Haendeler, Salma Amin, Roberta Baldi, ANNA CASCIO, Frank Edenhofer, Elena Taverna, Christopher Esk, Veronica Krenn, Silvia K. Nicolis
The paper uses CRISPR-LICHT to screen SOX2 targets in human brain organoids, identifying 28 new genes involved in neural progenitor lineage expansion and survival.
bioRxiv · Oct 27, 2026 · PreprintDevelopmental Biology