SMART: reference-free deconvolution for spatial transcriptomics using marker-gene-assisted topic models
Chen Xi Yang, Don D. Sin, RT Ng
SMART deconvolves spatial transcriptomics data without a reference, inferring cell type profiles and composition using marker genes, and outperforms existing methods when references are unavailable.
bioRxiv · Jun 20, 2023 · PreprintBioinformatics