BiophysicsThe Journal of Physical Chemistry BPeer-reviewed
In vitro-prepared A30P alpha-synuclein fibrils adopt the conserved and disease-relevant Greek key fold
Moses H. Milchberg, Owen A. Warmuth, Collin G. Borcik…·Chad M. Rienstra
The paper reports the high-resolution SSNMR structure of A30P mutant alpha-synuclein fibrils, showing a conserved Greek key fold not including the mutation site, and validates a method for comparing SSNMR spectra of Asyn polymorphs.
DOI 10.1021/acs.jpcb.6c02786