Discovery of Selective Nrf2 Activators from Natural Products: AComputational Screening Approach to Minimize Off-Target Effects on PXR and CYP2D6
Yue Wang, Yiwen Gong, Ruofei Li, Zhiru Li, Hongxia Cai, Li Fan, Yutong Li, Haomiao Ma
This paper identifies 10 ultraselective Nrf2 activators from natural products using computational screening to minimize off-target effects on PXR and CYP2D6.
bioRxiv · Apr 15, 2026 · PreprintBioinformatics