Author

Rustam Esanov

GlaxoSmithKline (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Organism:human· 3 Assay:CRISPR screen· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:perturbation response prediction· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Gunisha AroraiD· 2 shared Kaivalya ShevadeiD· 2 shared Laralynne PrzybylaiD· 2 shared Scot FedermaniD· 2 shared Shawn Shafer· 2 shared Yeqing Angela YangiD· 2 shared Abbas Abdallah· 1 shared Adam J. LittermaniD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenomics

Gunisha AroraORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Simultaneous single-cell CRISPR, RNA, and ATAC-seq enables multiomic CRISPR screens to identify gene regulatory relationships

Kaivalya Shevade, Yeqing Angela Yang, Kevin Feng, Karl Mader, Volkan Sevi̇m, Jacob Parsons, Gunisha Arora, Hasnaa A. Elfawy, Rachel Mace, Scot Federman, Rustam Esanov, Shawn Shafer, Eric D. Chow, Laralynne Przybyla

The paper introduces CAT-ATAC, a method combining CRISPR, RNA, and ATAC-seq in single cells to identify gene regulatory relationships and validate them with loss-of-function experiments.

bioRxiv · Feb 11, 2025 · PreprintGenomics

SAMHD1 Knockout iPSC model enables high lenti-viral transduction in myeloid cell types

Huinan Li, Maliha Afroze, Gunisha Arora, Scot Federman, Kaivalya Shevade, Yeqing Angela Yang, Phuong Nguyen, Rustam Esanov, Laralynne Przybyla, Adam J. Litterman, Shawn Shafer

The paper develops a SAMHD1 knockout iPSC model that enhances lentiviral transduction efficiency in myeloid cells, enabling better functional genomics studies in innate immunity and inflammatory diseases.

bioRxiv · Feb 4, 2025 · PreprintCell Biology

CRISPR/Cas9-Mediated Excision of ALS/FTD-Causing Hexanucleotide Repeat Expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro

Katharina E. Meijboom, Abbas Abdallah, Nicholas P. Fordham, Hiroko Nagase, Tomás Rodríguez, Carolyn Kraus, Tania F. Gendron, Gopinath Krishnan, Rustam Esanov, Nadja S. Andrade, Matthew J. Rybin, Melina Ramic, Zachary D. Stephens, Alireza Edraki, Meghan Blackwood, , Christian Mueller

This study removes a hexanucleotide repeat expansion in C9ORF72 using CRISPR/Cas9 in cell and animal models, reducing disease hallmarks.

Nature Communications · Oct 21, 2022Peer-reviewedMolecular Biology