Cross reactivity of antibodies against microbial proteins to human tissues as basis of Crohns disease and other autoimmune diseases
Peilin Zhang, Lawrence M. Minardi, J. Todd Kuenstner, Stephen M. Zekan, Feng Zhu, Yinling Hu, Rusty Kruzelock
The paper identifies microbial proteins reactive to autoantibodies in Crohn's disease and Sjögren's syndrome and shows their cross-reactivity to human tissues, suggesting a new mechanism for autoimmune disease pathogenesis.
bioRxiv · Apr 23, 2017 · PreprintMicrobiology