Author

Ryan A Williams

Fox Chase Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Rebecca G. SmithiD· 2 shared Yu LiuiD· 2 shared Amy M. WhitakeriD· 1 shared Carson CoheniD· 1 shared David A. LiberlesiD· 1 shared Hannah M. WilsoniD· 1 shared James Johnson· 1 shared Joseph Martini· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersGenomics

Rebecca G. SmithORCID

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3 papers

Recent·Most cited

Integrating epigenomic features reveals principles of chromatin-state organization

Joseph Martini, Ryan A Williams, Rebecca G. Smith, Yan Zhou, Yu Liu

The paper integrates epigenomic features to identify chromatin-state classes and shows Polycomb-associated chromatin drives cell-type-specific differences.

bioRxiv · Jul 23, 2026Genomics

Cohesin residence time gates 3D genome response to histone hyperacetylation

Rebecca G. Smith, Kathleen L Schiela, Hannah M. Wilson, Ryan A Williams, James Johnson, Carson Cohen, Wei-Ting Yueh, Amy M. Whitaker, Neil Johnson, Masato T. Kanemaki, Yu Liu

This study shows that cohesin residence time, not just its presence, determines how histone hyperacetylation affects 3D genome structure.

bioRxiv · Jul 4, 2026 · PreprintGenomics

A Dynamic Programming Approach for the Alignment of Molecules

Ryan A Williams, David A. Liberles

This paper introduces a dynamic programming algorithm for aligning molecules in SMILES format to quantify structural transformations in metabolic pathways, showing a midpoint dissimilarity peak in cyclical pathways and progressive similarity decrease in linear pathways.

bioRxiv · Jan 23, 2024 · PreprintBioinformatics