Acid Stress-induced plasma membrane ceramide arises from lysosome-plasma membrane fusion
Abhay Kanodia, Anne G. Ostermeyer‐Fay, María José Hernandez‐Corbacho, Ryan Chacon, Mehdi Damaghi, Yusuf Awni Hannun, Daniel Canals
The paper identifies a lysosome-to-plasma membrane pathway for stress-induced plasma membrane ceramide generation, showing lysosomal ceramide is transferred to the plasma membrane under acidic stress.
bioRxiv · Sep 22, 2026 · PreprintBiochemistry