Widespread exon definition is promoted by the U1 snRNP 70K subunit and requires sites of contact with RNA Polymerase II
Nova Fong, Ryan Sheridan, Benjamin Erickson, Rui Zhao, Aaron A. Hoskins, J. Matthew Taliaferro, David L. Bentley
The paper shows that U1-70K promotes exon definition by destabilizing U1-5' SS interactions, leading to exon skipping when depleted.
bioRxiv · Sep 9, 2026 · PreprintMolecular Biology