Cancer BiologybioRxivPreprint
DIRAS3 broadly suppresses signaling from diverse oncogenic KRAS hotspot variants through an inhibitory interface
Gamze Bildik, Hailing Yang, Weiqun Mao…·Zhen Lu
This study identifies DIRAS3 as a tumor suppressor that inhibits diverse oncogenic KRAS variants through a specific inhibitory interface, with a mimetic showing broad suppression of KRAS-driven signaling.
DOI 10.64898/2026.10.21.760748