DIRAS3 broadly suppresses signaling from diverse oncogenic KRAS hotspot variants through an inhibitory interface
Gamze Bildik, Hailing Yang, Weiqun Mao, Ritchel B. Gannaban, Vijay Kumar Bhardwaj, Md Nasir Uddin, S-Y Jung, Mariaelena Pierobon, Alison Gomeiz, Alemayehu Abebe Gorfe, John F. Hancock, Chris B. Marshall, Frank McCormick, Steven W. Millward, Junchen Liu, , Zhen Lu
This study identifies DIRAS3 as a tumor suppressor that inhibits diverse oncogenic KRAS variants through a specific inhibitory interface, with a mimetic showing broad suppression of KRAS-driven signaling.
bioRxiv · Oct 22, 2026 · PreprintCancer Biology