LXR alters CD4+ T cell function through direct regulation of glycosphingolipid synthesis
K. E. Waddington, G. A. Robinson, B. Rubio Cuesta, E. Chrifi-Alaoui, S. Andreone, K. S. Poon, I. Ivanova, L. Martin-Gutierrez, D. Owen, E. E. Jury, I. Pineda-Torra
This study shows LXR regulates glycosphingolipid synthesis in CD4+ T cells, altering lipid balance and reducing plasma membrane order, which dampens pro-inflammatory T cell function.
bioRxiv · Sep 2, 2020 · PreprintImmunology