Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins
S. M. Lim, V. E. Cruz, S. Antoku, G. G. Gundersen, T. Schwartz
The paper reports the crystal structure of FHOD1-Nes2G complexes, revealing that the FH3 domain of formins binds spectrin repeats and suggests overlapping functions of Nesprin1/2 in actin-bundle recruitment for nuclear movement.
bioRxiv · Jun 19, 2020Biochemistry