Extracellular vesicle cargo metabolome changes in response to the mesenchymal stromal cell microenvironment and influences cell quiescence and activation in a human breast cancer cell model
S. Bartlome, Y. Xiao, E. Ross, M. J. Dalby, C. C. Berry
This study shows that MSC-derived extracellular vesicles carry metabolites that maintain breast cancer cell dormancy, and their absence promotes activation under regenerative conditions.
bioRxiv · Dec 16, 2022 · PreprintCell Biology