Pharmacology & ToxicologybioRxivPreprint
Cysteamine-bicalutamide combination treatment restores alpha-ketoglutarate and corrects proximal tubule phenotype in cystinosis
A. Jamalpoor, C. A. van Gelder, F. A. Yousef Yengej…·M. J. Janssen
This study identifies alpha-ketoglutarate as a key metabolite in cystinosis and shows that combining cysteamine with bicalutamide corrects proximal tubule defects in cell models and zebrafish.
DOI 10.1101/2020.02.10.941799