Conformational plasticity and allosteric communication networks govern Shelterin protein TPP1 binding to human telomerase
S. Aureli, S. Raniolo, V. Limongelli
This study characterizes the structural properties of TPP1's OB-domain and reveals how conformational plasticity and allosteric communication networks affect TPP1-TERT binding, with implications for disease and therapeutic design.
bioRxiv · Feb 2, 2023 · PreprintBiochemistry