A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution
B. P. Paudel, A. L. Moye, H. Abou Assi, R. El-Khoury, S. B. Cohen, M. L. Birrento, S. Samosorn, K. Intharapichai, C. G. Tomlinson, M.-P. Teulade-Fichou, C. Gonzalez, J. L. Beck, M. J. Damha, A. M. van Oijen, T. M. Bryan
This study uses single-molecule techniques to show that telomerase can extend and unfold parallel telomeric G-quadruplexes, revealing it acts as a resolvase.
bioRxiv · Feb 26, 2020Biochemistry