Structural basis for lipid and copper regulation of the ABC transporter MsbA
J. Lyu, C. Liu, T. Zhang, S. Schrecke, N. Elam, G. Hocberg, D. Russell, M. Zhao, A. Laganowsky
This study uses native mass spectrometry and structural analysis to show how copper and lipids regulate the ABC transporter MsbA, revealing a conserved KLA binding site that modulates ATPase activity.
bioRxiv · Aug 4, 2022Biochemistry