The binding mechanism of Streptococcus suis accessory virulence factor and adhesin SadP to globotetraosylceramide
M. M. Johansson, E. Belurier, A. C. Papageorgiou, A. P. Sundin, J. Rahkila, T. Kallonen, U. J. Nilsson, S. Maatsola, T. K. M. Nyholm, J. Käpylä, J. Corander, R. Leino, J. Finne, S. Teneberg, S. J. Haataja
This study identifies the molecular mechanism by which SadP adhesin subtype PN binds Gb4, revealing a key role for Asn-285 in this interaction and its potential for targeted intervention against invasive S. suis strains.
bioRxiv · May 29, 2020 · PreprintMicrobiology