Amino acid restriction sensitizes lung cancer cells toferroptosis via GCN2-dependent activation of the integratedstress response
Viktor Garellick, Nadia Gul, Parvin Horrieh, Dyar Mustafa, Angana A.H. Patel, Martin Dankis, Samantha Alvarez, Johanna Berndtson, Saeed Mahdavi, Maria Schwarz, Andreas Persson, Fikret Zahirovic, Clotilde Wiel, Volkan I. Sayin, Per Lindahl
The paper shows that amino acid restriction increases lung cancer cell sensitivity to ferroptosis by activating GCN2 and the integrated stress response, without affecting glutathione levels.
Redox Biology · Dec 24, 2025Peer-reviewedCancer Biology