Author

Sagara N.S. Gurusinghe

Hebrew University of Jerusalem

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Bioinformatics· 1

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

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Julia M. ShifmaniD· 1 shared William F. DeGradoiD· 1 shared Yibing Wu· 1 shared

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2025-2025 · peak 1/yr

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Julia M. ShifmanORCID

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1 paper

Recent·Most cited

ProBASS: a language model with sequence and structural features for predicting the effect of mutations on binding affinity

Sagara N.S. Gurusinghe, Yibing Wu, William F. DeGrado, Julia M. Shifman

ProBASS predicts mutation effects on PPI binding affinity using sequence and structural features from ESM2 and ESM-IF1, achieving high correlation with experimental data.

Bioinformatics · May 1, 2025Peer-reviewedBioinformatics