Author

Sam Wadge

King's College London

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:long-read sequencing· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Kerrin S. SmalliD· 2 shared Matthew D. C. NevilleiD· 2 shared Peter J. CampbelliD· 2 shared Raheleh RahbariiD· 2 shared Rashesh SanghviiD· 2 shared Adrian Baez‐OrtegaiD· 1 shared Alex CaganiD· 1 shared Andrew R. J. LawsoniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Kerrin S. SmallORCID

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2 papers

Recent·Most cited

Sperm sequencing reveals extensive positive selection in the male germline

Matthew D. C. Neville, Andrew R. J. Lawson, Rashesh Sanghvi, Federico Abascal, My H. Pham, Alex Cagan, Pantelis A. Nicola, Tetyana Bayzetinova, Adrian Baez‐Ortega, Kirsty Roberts, Stefanie V. Lensing, Sara Widaa, Raul E. Alcantara, María Paz García, Sam Wadge, , Raheleh Rahbari

This study uses sperm sequencing to show that positive selection in the male germline leads to a higher risk of disease-causing mutations in offspring.

Nature · Oct 8, 2025Peer-reviewedGenetic & Genomic Medicine

Insights into non-crossover recombination from long-read sperm sequencing

Regev Schweiger, Sang-Jin Lee, Chenxi Zhou, Tsun-Po Yang, Katie Smith, Stacy Li, Rashesh Sanghvi, Matthew D. C. Neville, Emily Mitchell, Ayrun Nessa, Sam Wadge, Kerrin S. Small, Peter J. Campbell, Peter H. Sudmant, Raheleh Rahbari, Richard Michael Durbin

The paper uses long-read sperm sequencing to analyze non-crossover recombination events, finding variation in recombination rates and distinct mechanisms for non-crossover gene conversions.

bioRxiv · Jul 5, 2024 · PreprintGenetics