Author

Samuel Hunter

University of Colorado Boulder

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Approach:statistical model· 3 Assay:ATAC-seq· 2 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Robin D. DowelliD· 4 shared Mary Ann AlleniD· 3 shared Dylan J. TaatjesiD· 2 shared Benjamin EricksoniD· 1 shared Cathryn M Toomey· 1 shared David L. BentleyiD· 1 shared Deepa AjitiD· 1 shared Gilson J. SancheziD· 1 shared

Activity by Year

2023-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersGenetics

Robin D. DowellORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Fragile nucleosomes are essential for RNA Polymerase II to transcribe in eukaryotes

Lingbo Li, Samuel Hunter, Sonia M. Leach, Yonghua Zhuang, Haolin Liu, Jun‐Feng Gao, Qianqian Zhang, Timothy J. Stasevich, Hiroshi Kimurâ, Robin D. Dowell, Gongyi Zhang

The paper identifies four types of fragile nucleosomes that facilitate RNA Polymerase II transcription in human cells by analyzing histone modifications and Pol II activity.

bioRxiv · Oct 8, 2025 · PreprintGenetics

Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome

Kira Cozzolino, Lynn Sanford, Samuel Hunter, Kayla Molison, Benjamin Erickson, Meaghan CS Courvan, Taylor Jones, Deepa Ajit, Matthew D. Galbraith, Joaquin Maximiliano Espinosa, David L. Bentley, Mary Ann Allen, Robin D. Dowell, Dylan J. Taatjes

This study shows that inhibiting Mediator kinases CDK8/CDK19 suppresses hyperactive IFN signaling in Down syndrome by affecting transcription, splicing, and lipid metabolism.

eLife · Feb 10, 2025Peer-reviewedMolecular Biology

Histone Deacetylase Inhibitor Largazole Deactivates A Subset of Superenchancers and Causes Mitotic Chromosome Mis-alignment by Suppressing SP1 and BRD4

Gilson J. Sanchez, Zeyu Liu, Samuel Hunter, Quanbin Xu, Jessica Westfall, Graycen E. Wheeler, Cathryn M Toomey, Dylan J. Taatjes, Mary Ann Allen, Robin D. Dowell, Xuedong Liu

This study shows largazole suppresses superenhancer accessibility by inhibiting SP1 and BRD4, leading to mitotic chromosome misalignment and cell cycle arrest.

bioRxiv · Jan 29, 2025 · PreprintCancer Biology

Transcription dosage compensation does not occur in Down syndrome

Samuel Hunter, Robin D. Dowell, Josephina Hendrix, J. Freeman, Mary Ann Allen

The paper shows that transcriptional dosage compensation is absent in Down syndrome using real and simulated data, and highlights issues with standard analysis methods.

BMC Biology · Nov 9, 2023Peer-reviewedBioinformatics