Programmable Lipid Nanoparticle Targeting via Corona Engineering
Alişan Kayabölen, Cian Schmitt-Ulms, Alexander Elsener, Francesca Ferraresso, Keira A. Donnelly, Angela Xinyi Nan, Ian Harris, Samantha R. Sgrizzi, Aroosa Anwer, I. Balestra, Patrick Paine, Sanah Langer, Christopher J. Fell, Jonathan S. Gootenberg, Omar O. Abudayyeh
This paper develops strategies to redirect lipid nanoparticle targeting away from the liver and toward specific tissues using engineered proteins and antibody conjugation.
bioRxiv · Mar 1, 2026 · PreprintBioengineering