Combined Menin and XPO1 inhibition drive synergistic antileukemic activity in KMT2Ar and NPM1-m AML
Md. Hafiz Uddin, Sandhya Dhiman, Yufen Han, Amro Aboukameel, Vikram Dhillon, Jeff Justin Aguilar, Steven A. Buck, Abhinav Deol, Julie L. Boerner, Lisa Polin, Linda V. Kessler, Francis Burrows, Jay Yang, Asfar Sohail Azmi, Jaroslaw Pawel Maciejewski, , Suresh Kumar Balasubramanian
This study shows that combining Menin and XPO1 inhibitors synergistically inhibits KMT2A-r and NPM1-m AML cell growth and improves survival in xenograft models.
bioRxiv · Mar 13, 2026 · PreprintCancer Biology