Mapping the sequence determinants of constitutive activity in GPCRs
Matthew K Howard, Sara Whiteman, Patrick Rockefeller Grimes, Christian B Macdonald, Aashish Manglik, Willow Coyote-Maestas
The paper measures basal activity across the human GPCR family on a single scale and identifies key residues that influence constitutive signaling.
bioRxiv · Nov 3, 2026 · PreprintBiochemistry