Tissue architecture and immune niches govern ctDNA release in colorectal cancer
Stefan Kühberger, Katja Sallinger, Christin-Therese Müller, Maria Escriva Conde, Sergio Marco Salas, Silvia Andaloro, Christine Beichler, Ricarda Graf, Karin Pankratz, Julia Enzi, Sarah Binder, Martina Scheiber, Lilli Bonstingl, Jasmin Blatterer, Stefan Uranitsch, , Ellen Heitzer
This study identifies tissue architecture and immune niches as key factors influencing ctDNA release in colorectal cancer by integrating spatial transcriptomics and in situ mutation detection.
bioRxiv · Nov 28, 2025 · PreprintCancer Biology