Pooled CAR-T screening in nonhuman primates identifies designs with enhanced proliferation, trafficking, and persistence
Lucy H. Maynard, Eric J. Cavanaugh, Haiying Zhu, Carly E. Starke, Sarah M. Doherty, Teresa Einhaus, Ailyn Perez, Laurence Stensland, Michelle Hoffman, Veronica Nelson, Sarah Herrin, Chad Littlewood, Kaycee Camou, Erica Wilson, Christopher Wessel, , Christopher W. Peterson
This study screens CAR-T designs in nonhuman primates and identifies MyD88-CD40 costimulatory domains as superior for proliferation, trafficking, and persistence.
bioRxiv · Mar 5, 2025 · PreprintImmunology