Author

Sarah Murphy

Boston Children's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Neuroscience· 3 Developmental Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Organism:C. elegans· 1

Frequent Co-Authors

Beth StevensiD· 2 shared Evan Z. MacoskoiD· 2 shared Samuel E. MarshiD· 2 shared Tushar KamathiD· 2 shared Abdulraouf AbdulraoufiD· 1 shared Adam M. H. Young· 1 shared Alec J. WalkeriD· 1 shared Aleksandrina GoevaiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Beth StevensORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Sex-divergent trajectories of hippocampal and cortical NMDA receptor density across the Alzheimer 's disease continuum

Maricedes Acosta‐Martínez, Vanessa Carter, Aviram Nessim, Sarah Murphy, Jasbeer Dhawan, Thomas G. Beach, Geidy E. Serrano, Erin E. Sundermann, Anat R Biegon

The paper examines sex differences in NMDA receptor density across Alzheimer's disease stages and finds sex-specific changes in mild cognitive impairment.

bioRxiv · Aug 7, 2026 · PreprintNeuroscience

FKS1/2-variant independent mechanisms underlying the emergence of resistance in echinocandin-refractory Candida auris infections

Hugh Gifford, Arnab Pradhan, Ben A Caswall, Sarah Murphy, Ian Leaves, Matt B. Edmondson, Tanmoy Chakraborty, Duncan Wilson, Surabhi K. Taori, Neil A. R. Gow, Rhys A. Farrer, Alistair J. P. Brown, Tihana A. Bicanic

This study identifies FKS1/2-variant independent mechanisms of echinocandin resistance in Candida auris through genomic and phenotypic analysis of clinical isolates.

bioRxiv · Jan 18, 2026 · PreprintMicrobiology

Tolerance thresholds underlie responses to DNA damage during germline development

Gloria Jansen, Daniel Gebert, Tharini Ravindra Kumar, Emily S. G. Simmons, Sarah Murphy, Felipe Karam Teixeira

The paper shows that germ cells in Drosophila tolerate DNA damage during meiosis but are sensitive to it during mitosis, revealing a threshold for DNA damage tolerance in germline development.

Genes & Development · Jul 25, 2024Peer-reviewedDevelopmental Biology

A resource for generating and manipulating human microglial states in vitro

Michael-John Dolan, Martine Therrien, Saša Jereb, Tushar Kamath, Vahid Gazestani, Trevor Atkeson, Samuel E. Marsh, Aleksandrina Goeva, Neal M. Lojek, Sarah Murphy, Cassandra White, Julia Joung, Bingxu Liu, Francesco Limone, Kevin C. Eggan, , Beth Stevens

This paper develops a platform to model and manipulate human microglial states in vitro using single-cell RNA sequencing and genetic tools, identifying disease-associated transcriptional signatures.

Nature Immunology · Jul 27, 2023Peer-reviewedNeuroscience

Single Cell Sequencing Reveals Glial Specific Responses to Tissue Processing & Enzymatic Dissociation in Mice and Humans

Samuel E. Marsh, Alec J. Walker, Tushar Kamath, Lasse Dissing‐Olesen, Timothy R. Hammond, Yvanka de Soysa, Adam M. H. Young, Sarah Murphy, Abdulraouf Abdulraouf, Naeem M. Nadaf, Connor Dufort, Alicia C. Walker, Liliana E. Lucca, Velina Kozareva, Charles R. Vanderburg, , Beth Stevens

The paper shows enzymatic dissociation causes gene expression changes in microglia and proposes a protocol to reduce these artifacts in scRNA-seq.

Nature Neuroscience · Mar 1, 2022Peer-reviewedNeuroscience