Sarah Wehrle

The paper presents a synthetic immune cell platform integrated with machine learning to predict TCR specificity to peptide-HLA antigens across the human proteome.

This study designs stem-epitope mimetics using computational methods to elicit broadly reactive antibodies against influenza viruses.

This paper designs chimeric influenza hemagglutinins that combine antigenic surfaces from different strains to elicit cross-group immunity and neutralize multiple strains.

This paper introduces a computational framework for designing functional proteins by integrating folding and sequence design, showing that functional motifs can be embedded without requiring the global energy minimum.