Author

Sean Lee

Arc Research InstitutePrimary ORCID profile (0009-0008-9188-0440 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Sean LeeiD1 paper · The University of Texas MD Anderson Cancer Center

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:large language model· 1

Frequent Co-Authors

Hani GoodarziiD· 2 shared Siyu CheniD· 2 shared Ali Saberi· 1 shared April PawlukiD· 1 shared Bahar Zirak· 1 shared Christian B. MacdonaldiD· 1 shared Kian Yousefi· 1 shared Matthew K. HowardiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersGenomics

Hani GoodarziORCID

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2 papers

Recent·Most cited

The adaptive architecture of tRNA dependencies across physiological tumor environments

Siyu Chen, Trey Charbonneau, Kian Yousefi, Bahar Zirak, Sean Lee, Tanvi Joshi, April Pawluk, Vijay Ramani, Hani Goodarzi

The paper maps tRNA dependencies in cancer cells across different environments, finding that tRNA dependencies are environmentally sensitive while some dependencies are shared across cell lines.

bioRxiv · Oct 9, 2026 · PreprintGenomics

A Suite of Foundation Models Captures the Contextual Interplay Between Codons

Mohsen Naghipourfar, Siyu Chen, Matthew K. Howard, Christian B. Macdonald, Matvei Khoroshkin, Sean Lee, Ali Saberi, Timo Hagen, Mohammad R. K. Mofrad, Willow Coyote‐Maestas, Hani Goodarzi

The paper introduces cdsFM, a suite of codon-resolution large language models that predict the functional consequences of synonymous codon choices and identify pathogenic variants.

bioRxiv · Oct 10, 2024 · PreprintGenomics