BioinformaticsGenome BiologyPeer-reviewed
Reconstructing subclonal composition and evolution from whole genome sequencing of tumors
Amit G. Deshwar, Shankar Vembu, Christina K. Yung…·Quaid Morris
This paper introduces PhyloWGS, a method for subclonal reconstruction from whole genome sequencing data, showing it can accurately recover subclonal composition, genotype, and phylogeny using both SSMs and CNVs.
DOI 10.1186/s13059-015-0602-8