Deep learning modeling of ribosome profiling reveals regulatory underpinnings of translatome and interprets disease variants
Jialin He, Lei Xiong, Shaohui Shi, Chengyu Li, Kexuan Chen, Qianchen Fang, Jiuhong Nan, Ke Ding, Jingyun Li, Yuanhui Mao, Carles A. Boix, Xinyang Hu, M Kellis, Xushen Xiong
The paper introduces Translatomer, a transformer model that predicts cell-type-specific translation from mRNA and sequence data, identifies disease variants affecting translation, and reveals non-eQTL regulatory mechanisms.
bioRxiv · Feb 26, 2024 · PreprintGenomics