HMGA2 Expression in Pancreatic Ductal Adenocarcinoma Controls Tumor Microenvironment and Immunosuppression via IL1α
Naomi Yamamoto, Stephanie Dobersch, Tess M. Robertson, Jae Hyung Sim, Adrianne Wallace-Povirk, Nayvin W. Chew, Alexander E. Orellana, Joana E. Aggrey-Fynn, Liberalis Debraj Boila, Aidan Schutter, Ian M. Loveless, Gun Ho Jang, Shayan Avanessian, Gregory Lawrence Beatty, Suni R Hingorani, , Sita Kugel
This study shows HMGA2 in PDAC drives immunosuppressive TME by upregulating IL1α, which promotes CAFs and reduces CD8+ T cells, and blocking IL1 improves tumor control with KRAS inhibitors.
bioRxiv · Oct 6, 2026 · PreprintCancer Biology