Robust and Reliable de novo Protein Design: A Flow-Matching-Based Protein Generative Model Achieves Remarkably High Success Rates
Junyu Yan, Zibo Cui, Wenqing Yan, Yuhang Chen, Mengchen Pu, Shuai Li, Sheng Ye
The paper introduces OriginFlow, a protein generative model that achieves high success rates in designability, diversity, and functional design of proteins, validated through wet-lab experiments.
bioRxiv · Apr 29, 2025 · PreprintBioengineering