Avs2 drives non-canonical tetrameric assembly of trypsin-like domain for anti-phage defense
Lijie Guo, Pingping Huang, Wenhui Liu, Jingxian Liu, Dongyang Xu, Shengbin Yu, Zongqiang Wang, Lei Zhang, Zhaoxing Li, Xu Cao, Qian Yang, Mengjun Cheng, Nannan Wu, Meiling Lü, Lian‐Wen Qi, , Meirong Chen
The paper elucidates the molecular mechanism of the Avs2-trypsin-MBL system, revealing how phage terminase recognition triggers tetramerization and activation of the system for anti-phage defense.
bioRxiv · Aug 26, 2026 · PreprintMicrobiology