Prolonged Crowding Initiates Tumor Invasion with Mechanomemory by Pressure-Sensation of Membrane Domains
Xinbin Zhao, Min Tan, Long Li, Xubo Lin, Zekun Li, Xiaohuan Wang, Bingqi Song, Zheng Guo, Tailin Chen, Sen Hou, Jiehou Fan, Shijiang Wang, Yun Zhang, Yubo Fan, Jing Du
This study shows that prolonged crowding induces an invasive phenotype in cancer cells through mechanomemory, mediated by membrane domain disaggregation under compressive stress.
Acta Biomaterialia · Jun 30, 2026Peer-reviewedCancer Biology