In Vivo Mechanisms of Chemotherapy-Induced Acute Follicle Loss in the Human Ovary: An Individual-Oocyte Transcriptomic Analysis from Human Ovarian Xenografts
Shiny Titus, Katarzyna Joanna Szymańska, Biran Musul, Volkan Turan, Enes Taylan, Rolando García-Milian, Sameet S. Mehta, Kutluk Oktay
The paper uses single-cell RNA sequencing to show cyclophosphamide induces apoptosis in human ovarian primordial follicles, not follicle growth activation, causing acute ovarian reserve depletion.
bioRxiv · Jun 23, 2020 · PreprintMolecular Biology