RNA splicing dynamics in CD8 T cells uncovers isoforms that impact T cell-mediated cancer immunotherapy
Shay Tzaban, Priyanga Appasamy, Elad Zisman, Shiri Klein, Reyut Lewis, Houlin Yu, Akanksha Khorgade, Marc A. Schwartz, Moshe Sade-Feldman, Thomas Eisenhaure, Oren Parnas, Aron Popovtzer, Cyrille J. Cohen, Eric Shifrut, Aziz M. Al’Khafaji, , Michal Lotem
The paper constructs a single-cell splicing atlas of human CD8 T cells and identifies isoform-specific immune checkpoints that enhance effector function and tumor control.
bioRxiv · Sep 7, 2025 · PreprintImmunology